Definition

Noun: The non-living material located between the cells of a tissue. It is a complex substance produced by the cells themselves and provides structural and biochemical support to the surrounding cells.

Usage

This is a scientific term used primarily in biology, histology, and medicine to describe the extracellular matrix that fills the spaces between cells in connective tissues.

Examples

• Noun:
  • Cartilage strength comes from its dense intercellular substance.
  • The pathologist examined the intercellular substance for signs of degradation.

Advanced Usage

• "Ground substance": A common synonym, specifically referring to the gel-like, amorphous component of the intercellular substance.
  • The ground substance of the connective tissue allows for nutrient diffusion.

Variants and Related Words

• Extracellular matrix (ECM) (n): A more modern and comprehensive term encompassing the intercellular substance along with fibrous proteins like collagen.

  • The extracellular matrix regulates cell behavior.

• Matrix (n): In biological contexts, often used interchangeably with intercellular substance or extracellular matrix.

  • The bone matrix is a calcified intercellular substance.

Synonyms

• Ground substance
• Extracellular matrix (broader term)

Notes on Meaning

This term specifically refers to the non-cellular component. It is distinct from the cells themselves and is crucial for providing tissues with their mechanical properties and for facilitating cell communication.

Noun

1. the body substance in which tissue cells are embedded